You’ve probably heard about the therapeutic potential of CBD, the “healing cannabinoid” as it’s often referred to. You might even know that THC has its own use in wellness, from managing mood to supporting better sleep. But what does THC and CBD do together?
After all, the real power of cannabis comes from the entourage effect. This is where multiple cannabinoids (and ideally, even terpenes and flavonoids) can work in synergy to build upon each other's potential.
We’ve put together this guide highlighting the benefits of CBD and THC together to show you some of the different ways our THC CBD mints or THC CBD shots can support your day-to-day lifestyle. Whether you’re looking to add pep to your step or want to unwind, visit Mr. Moxey’s!
The Basics of CBD and THC
Before we dive into the potential benefits of THC and CBD let’s take a step back and explain what exactly these compounds are and how they work in the body.
Overview of Cannabinoids
Cannabis contains more than 100 naturally occurring compounds known as cannabinoids - THC and CBD are just the most well-known. Others include CBN, CBG, CBC, the list goes on and on.
These are the chemical messengers that make you feel something when you consume cannabis. They bind to a network of receptors in the body, known as the endocannabinoid system (ECS).
These receptors influence everything from mood to sleep, pain response, immune health, and more. There are two different types of receptors:
- CB1 receptors are found mostly in the brain and central nervous system (CNS). They influence mood, memory, and perception.
- CB2 receptors are located in the immune system and peripheral tissues. They help dictate your inflammatory and immune response.
THC and CBD interact with these receptors in different ways to bring out different effects. That said, let’s take a closer look at the two cannabinoids in isolation before bringing them together.
What is CBD?
CBD (cannabidiol) is the non-intoxicating cannabinoid found in marijuana and hemp, meaning it won’t get you high. No matter how much you take, its role is limited to providing therapeutic effects. Some of the most well-documented uses for CBD include:
- Promoting relaxation and stress relief without sedation
- Supporting pain management by interacting with inflammation pathways
- Helping you sleep better by regulating circadian rhythms and calming the CNS
- Improving focus and mood stability through serotonin and dopamine regulation
One other unique benefit of CBD is how it can balance THC’s psychoactive effects, keeping anxiety or paranoia at bay. After all, the fear of getting “too high” is one of the things holding people back from adding cannabis to their self-care rituals.
What is THC?
THC (tetrahydrocannabinol) is what people associate with the “high” from marijuana. Make no mistake, though, it also brings its own therapeutic potential to the table. THC binds with CB1 receptors in the brain to elicit that euphoric feeling - but here’s what else it can do:
- Ease aches and pains by modulating pain perception in the CNS
- Stimulate appetite to help those struggling with eating disorders or loss of appetite
- Supporting better sleep for individuals with insomnia or restlessness, especially when it’s caused by an overactive mind
- Relaxing tense, overactive muscles for conditions involving tension or spasms
- The euphoric feeling can turn a bad mood around since it’s dopamine being released
While THC has traditionally been heavily regulated, the 2018 Farm Bill left open a legal loophole that means you can buy these products legally in most states.
The only states we currently can’t ship to are Oregon and Washington. However, our products are available in both states - you can find us in person using our store locator.
Key Differences Between THC and CBD
THC and CBD are on total opposite ends of the cannabinoid spectrum. One gets you high, the other doesn’t. One is legal almost everywhere, the other is more closely regulated. So before we look at the benefits of CBD and THC together, here’s an overview of how they’re different:
| Feature | CBD | THC |
|---|---|---|
| Psychoactive? | No – does not produce a high | Yes – binds to CB1 receptors, creating euphoria |
| Legality | Legal in most areas if derived from hemp (under 0.3% THC) | Heavily regulated, varies by state/country |
| Interaction with ECS | Indirect – modulates receptor activity | Direct – binds to CB1 and CB2 receptors |
| Common Uses | Relaxation, stress relief, inflammation, focus, sleep support | Pain relief, appetite stimulation, sleep, mood enhancement |
| Side Effects | Minimal – may include drowsiness at high doses | Can cause dry mouth, dizziness, increased appetite, or anxiety at high doses |
These nuances are actually what make using THC and CBD together so powerful. They can round each other out and build upon each other’s strengths. So, what does THC and CBD do together?
What Does THC and CBD Do Together? The Benefits of CBD and THC Together
We mentioned earlier that cannabis is meant to be experienced as nature intended - as true-to-strain as possible. So many products isolate out CBD for those who just want therapeutic potential or THC for those who just want a high. The truth is, they’re better together.
This synergy is known as the entourage effect - the idea that cannabinoids, terpenes, and other natural compounds in cannabis can amplify each other’s effects. This leads to quite a few benefits of CBD and THC together:
Reduced THC Side Effects
Even those who want to get high don’t want to get too high. If you’re lucky enough to never have experienced this, it can leave you feeling anxious, paranoid, and generally just uncomfortable. But CBD has a unique ability to mellow out THC’s intensity, reducing these side effects.
That doesn’t mean you’re not going to feel any sort of high when combining THC and CBD. Instead, the effects will feel softer and more balanced. You’ll feel mentally sharp even through the euphoria - it’s the best of both worlds!
Supporting a Healthy Inflammatory Response
CBD and THC both have the potential to regulate your body’s inflammatory response on their own. The effects are more powerful when the two cannabinoids are brought together, though.
That’s because they work through different ECS receptors. CBD interacts with CB2 receptors to modulate the immune response and keep inflammation in check.
Meanwhile, THC binds to both CB1 and CB2 receptors to more actively manage discomfort while supporting the body’s natural healing process. Speaking of discomfort…
Helping Ease Aches and Pains
You probably knew CBD has the potential to alleviate aches and pains before coming here today - but you may not have realized THC also brings pain relief potential to the table as well!
What makes THC unique is that it can actually alter pain perception, easing the intensity of discomfort. CBD also has analgesic (pain-relieving) properties, but it works differently by interacting with receptors that regulate inflammation and nerve signaling.
There are so many different situations where it might make sense to combine these two cannabinoids to experience the benefits of CBD and THC together for pain management:
- Chronic pain management (arthritis, fibromyalgia, nerve pain)
- Post-workout recovery to help with sore muscles and tension
- Joint discomfort relief without relying on pharmaceuticals
The best part is there aren’t any sketchy side effects associated with cannabis (especially when consumed orally to protect your lungs). It’s a far safer alternative to over-the-counter painkillers and all the question marks they come with.
Balancing Mood and Managing Stress
What comes to mind when you think about using cannabis? For most people, it’s probably a sense of relaxation and bliss. That’s because both CBD and THC can stabilize and balance your mood.
Again, though, they do so differently - which is why bringing them together is so powerful for managing stress. CBD supports serotonin activity to regulate your body’s stress response while THC actually encourages dopamine release, bringing out that chill, euphoric feeling.
This dynamic duo can help ease a racing mind and help you unwind after a long, hectic day. It can create a calm, uplifted state without lulling you into a sedated state.
Keeping Nausea at Bay
THC has been used to manage nausea and stimulate appetite for decades. It’s relied on by chemotherapy patients and those with eating disorders for this reason alone.
But, the tricky part is that THC can sometimes have the opposite intended effect and cause dizziness or discomfort. That’s where CBD comes in to help regulate gut motility and reduce nausea. It makes using cannabis more predictable and gentle.
Tips on Mixing CBD and THC to Tap Into the Entourage Effect
You’re probably looking to harness the benefits of CBD and THC together after discovering all that this powerful pairing can do for your health and happiness.
It’s just a matter of understanding the optimal ratios for your intended goals, finding the right consumption method, and tailoring dosage to your experience level and desired effects. Here are some tips to set you out on the right foot.
Different Ratios of CBD to THC
The specific ratio of CBD to THC impacts the response in your body. For instance, high CBD, low THC (20:1 or 10:1) is best for subtle relaxation and stress relief, or even inflammation support without any psychoactive effects. You won’t feel high at all.
But a more balanced CBD to THC ratio, say 2:1 or 1:1, will elicit a different outcome. You likely will feel high, or at least a gentle wave of euphoria will come over you. This is a better approach for deeper relaxation and mood support, and can provide more potent pain relief as well.
There are cases where a THC-dominant ratio makes sense too, like a 1:2 or 1:5 CBD to THC ratio. This can supercharge pain relief, sleep support, and appetite stimulation. It’ll also get you high, but you likely won’t feel overwhelmed since CBD is there to mellow out the intensity.
There may be some trial and error to find the perfect ratio for your desired effects. Here at Mr. Moxey’s you’ll gain access to quite a few different product formulations.
Our Calm Mints are a 40:1 ratio of CBD to THC, whereas our Sleep Mints are 1:1 (technically 1:1:1 since CBN is included). Our Stress Mints are 2:1. There’s something for everyone!
Consumption Methods
Wait, mints? That’s right - there are so many different ways to tap into the potential of cannabis, and we’ve come up with a really unique approach through our mints.
They’re the best way to enjoy cannabis on the go, discreetly. They also provide slow-release, sustained effects throughout the day. They’re a great way to microdose cannabis.
But, cannabis shots are also a popular way to enjoy cannabis. We’ve formulated an array of shots with complementary ingredients like ginger, agave, lemon, turmeric, blood orange, elderberry, and more.
Other ways to enjoy cannabis include tinctures, which are fairly similar to our mints but with a bit more hassle and inconvenience with dosing and consumption.
While vaping and smoking are more common, we don’t love the idea of putting anything but air into our lungs. Plus, that’s not really a great way to harness the therapeutic benefits of CBD and THC together with less control over dosage and cannabinoid ratio. Effects are short-lived, too.
Dosage Decisions
One of the biggest hurdles to experiencing the benefits of CBD and THC together is finding the dosage sweet spot. Too low a dose won’t produce any sort of tangible effect, while overdoing it can derail your day or leave you feeling anxious and paranoid - even with CBD modulating THC!
Our advice is to always go low and slow, practicing titration. This means starting with as little as 1-2mg of THC and gauging how that affects you over the course of a few hours. If it’s not enough, try 2.5-5mg next time and see how that works.
The goal is to find the minimum effective dosage (MED) where you feel the way you want without overdoing it. This keeps your tolerance low, too, so you don’t have to keep taking more and more.
Invest in Your Health and Happiness at Mr. Moxey’s!
If you’re ready to see for yourself how combining THC and CBD can support your health and happiness, take the next step at Mr. Moxey’s. We believe in intentional cannabis use where every product serves a purpose, and we’ve developed those products just for you.
Microdosing just got a whole lot easier, so you can continue to live your life without feeling stoned or sedated. Instead, our product lineup helps you relax, focus, and find relief on your own terms.
Whether you're exploring cannabis for the first time or refining your routine, our carefully crafted mints and edibles can help you feel your best without any unpredictability.
Wellness is personal. Your cannabis experience should be, too. Shop today and see what keeps our customers coming back for more!
Final Words on the Benefits of CBD and THC Together
So what does THC and CBD do together? As we wrap up this guide to the benefits of THC and CBD we hope you have a better understanding of the entourage effect and why we here at Mr. Moxey’s choose to formulate products with multiple cannabinoids for maximum wellness.
From stress relief and mood support to pain management and better sleep, the amplified benefits of CBD and THC together can help you use cannabis therapeutically without getting too high. We’ve made it easier and less stressful than ever with our unique product lineup.
Whether you want to try a sleep shot to get a better night’s rest or want to stir up your creative juices during the workday with a focus shot, or turn off a racing mind with an anxiety shot - there’s something for you at Mr. Moxey’s.
Discover the perfect CBD-to-THC balance for your needs today.
